Sickle Cell Anaemia with Antiglobulin Positive Autoimmune Haemolytic Crisis

Sickle Cell Anaemia with Antiglobulin Positive Autoimmune Haemolytic Crisis

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Dear Editor, Immune-mediated haemolytic crises can worsen congenital anemias, and although autoantibodies have been identified, they are not frequently associated with overt Autoimmune Haemolytic Anaemia (AIHA) [1].Sickle Cell Disease (SCD) is characterized by the presence of haemoglobin S (HbS), an abnormal type of haemoglobin that can form polymers in erythrocytes and distort Woks the structure of Red Blood Cells (RBC).This can lead to intravascular sickling, haemolytic anaemia, and vaso-occlusive crisis caused by persistent narrowing of the tiny blood arteries.Autoimmune disease can result from various mechanisms, including the alteration of RBC membrane antigens, molecular mimicry, the T-Shirt propagation of hidden epitopes, and the destruction of innocent bystanders [2].